Melatonin, the neuro‐hormone synthesized during the night, has recently seen an unexpected extension of its functional implications toward type 2 diabetes development, visual functions, sleep disturbances, and depression. Transgenic mouse models were instrumental for the establishment of the link between melatonin and these major human diseases. Most of the actions of melatonin are mediated by two types of G protein‐coupled receptors, named MT1 and MT2, which are expressed in many different organs and tissues. Understanding the pharmacology and function of mouse (...) MT1 and MT2 receptors, including MT1/MT2 heteromers, will be of crucial importance to evaluate the relevance of these mouse models for future therapeutic developments. This review will critically discuss these aspects, and give some perspectives including the generation of new mouse models. (shrink)

The pages that follow offer a critical survey of the motivic pursuit of a sober and wakeful way of life in old and late Stoicism (esp. Seneca’s Letters, Epictetus’ Discourses, and Marcus Aurelius’ Meditations). The aim is to show the key role that this motif plays in the Stoic conceptualization of conversion to philosophy and the school’s protreptic or rhetoric of conversion, that is to say, the forms of speech and literary strategies employed to instruct their addressees about what they (...) understood by conversion to philosophy and exhort them to change in their way of life. Wakefulness and soberness (and their counterparts, sleep and drunkenness) have been brought up occasionally in studies on Stoic ethics or moral philosophy. Yet, scholarship in the field has, to date, failed to identify the unique light this motif sheds on the Stoic pedagogical heuristics and conversion experience. T. Bénatouïl 2006, however, has already pointed out, in a study on the practical dimension of Stoicism, that despite its apparent triviality, the Stoic discussion on the sage’s use of wine and drunkenness unveils significant insights into the principles which govern the sage’s whole way of life. With a similar conviction, I hope that what follows may also elucidate the unparalleled lens that wakefulness and soberness as a motif for conversion provides for our understanding of the Stoic pursuit of a way of life in wisdom and virtue and its distinctiveness in the interaction process between traditions that characterized the ancient Mediterranean context. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:American Journal of Philology 122.2 (2001) 223-253 [Access article in PDF] The Economics Of Roman Elegy: Voluntary Poverty, The Recusatio, And The Greedy Girl Sharon L. James Roman love elegy presents sexual relationships between elite men and women of lower status in apparently reversed gender and power positions, so that the male is enslaved to his beloved domina. This metaphorical reversal, however, actually retains standard Roman social structures, (...) suggesting an inequity even within a private love affair: rather than sharing goals and desires, lover and beloved stand in a gendered opposition. Historically, elegy has been interpreted from the perspective of its male speakers, and much scholarship has focused on the characterizations of those speakers. But as it is legitimate to study the male elegiac speakers' viewpoint, it is likewise appropriate to consider that of his preferred love object and frequent addressee, the elegiac doctapuella. Since much of elegy is directed at a fictive, if named, woman, 1 such an approach may illuminate some of its rhetorical strategies and gender values, particularly as they derive from and relate to Roman gendered power constructs. Since elegy in particular generically anticipates the perspective of the docta puella, 2 and makes it a structural element of the [End Page 223] genre, to read elegy from that perspective provides both a necessary corrective or balance to the dominant male voice of the genre and a revelation of its inherent disingenuity. I will examine two related topoi of elegy--the recusatio and the problem of the "greedy girl"--from the position of the puella, a viewpoint that demonstrates the relationship between these two topoi and reveals the engine of Roman love elegy to be self-interested sexual persuasion rather than sincere confession of passion. 3This approach requires identifying the elegiac puella, the counterpart to the recognizable elite male speaker of Roman love elegy, the lover-poet. In my view, she is a fictional construct based upon the courtesan of New Comedy--that is, she is an elegant, educated woman who has no financial security and thus must earn her own living while she can. 4 [End Page 224] Identifying her in this way has several consequences, but only two concern us here.The first consequence is that many apparently individual character traits in an elegiac puella turn out to be professionally motivated behavior, as dictated by both Dipsas and Acanthis in Amores 1.8 and Propertius 4.5. A primary example is greed, for which the elegiac speakers never tire of criticizing their puellae, as though avaritia were a character flaw of a specific woman rather than a professional obligation. 5 Thus, when the lover-poet in Propertius 2.16 complains that Cynthia always weighs the purses of her lovers ("semper amatorum ponderat una sinus," 2.16.12), he is actually describing the behavior prescribed for her not only by the lena Acanthis, in poem 4.5 but in the pages of Roman comedy as well. 6 Comedy routinely presents the courtesan's needs and the young lover's desires as being at odds. The same structure of economic opposition governs the elegiac love affair: the puella plays a generic, professional part that may conflict with her personal inclinations or character (cf. Thais and Bacchis in Ter. Eun. and Hecyra). She is also presented as retaining her self-control while her impassioned lover loses his. 7 Like other courtesans of Roman comedy, Phronesium (Plaut. Truc.) is fully aware of both her present material and social circumstances and the [End Page 225] expiration date of her professional viability. Thus she necessarily seeks money and gifts from her lovers, both to maintain her attractions as an elegant woman 8 and to prepare for the future when she will no longer be able to practice her profession. Her literary granddaughter, the elegiac puella, does likewise (see, as noted above, the instruction of Acanthis and Dipsas, particularly lines 59-62 of Prop. 4.5 and 49-56 of Am. 1.8), and here it is worth recalling that even the male speakers of elegy allude... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Journal of Aesthetic Education 38.2 (2004) 105-115 [Access article in PDF] Intimacy and Monumentality in Chandigarh, North India: Le Corbusier's Capitol Complex and Nek Chand Saini's Rock Garden Sharon Irish School of Architecture University of Illinois, Urbana-Champaign Chandigarh's Le Corbusier: The Struggle for Modernity in Postcolonial India, by Vikramaditya Prakash. Seattle: University of Washington Press, 2002, 179pp., $35.00 cloth. The seventh century poet and philosopher Dharmakirti wrote (...) of the path we each must make: No one behind, no one ahead, The path the ancients cleared has closed. And the other path, everyone's path, easy and wide, goes nowhere. I am alone and find my way.1The image in Figure 1 shows the bottom of a concrete ramp that angles back upon itself as it connects two levels of the government complex in Chandigarh and ends in a grassy hillside that has several dirt paths cutting across it. The concrete ramp begins just to the left of Le Corbusier's Assembly Hall (Figure 2). What I hope is evident from just two images is the contrast between the curving, unplanned path that pedestrians have made as they leave the bottom of the ramp, and the axial, monumental path implicit in the organization of the large concrete plaza in front of the Assembly Hall. One is informal and intimate because of the many footprints that have worn away the grass; the other is formal and monumental in its carefully controlled framing of a sculptural presence. They are two very different paths, offering different rewards as we wander upon them.As Vikramaditya Prakash's book, Chandigarh's Le Corbusier, emphasizes, the Capitol Complex derived from Le Corbusier's personal mythology, transmogrified somewhat by the site, the politics, and the climate. Le Corbusier "considered it the true mission of modern architecture to reestablish the aesthetic and poetic forms necessary for the liberation and deliverance of...modern man."2 Le Corbusier's monumentalism, then, was imposed on Chandigarh's landscape and the inhabitants with the assumption that he knew best what architecture was appropriate for "liberation." While there are many aspects of his designs to appreciate and admire, his buildings only indirectly address the visitor, preferring uncanny to intimate relationships.3 [End Page 105] Click for larger viewFigure 1 The bottom of the ramp leading into a path toward the Trench of Consideration, Capitol Complex, Chandigarh. Photo by the author. Click for larger viewFigure 2 Façade of the Assembly Building, Le Corbusier, 1953-61, Chandigarh. Photo by the author. [End Page 106]For six months in 1999, I lived in Chandigarh within a few blocks of Le Corbusier's government complex and another compelling place, the nearby and unrelated Rock Garden. While the paths at the Government Complex are, for the most part, empty, those in the Rock Garden are not and provide chances for intimate interactions that are only hinted at underneath Le Corbusier's concrete ramp. Poignant informality in Le Corbusier's government sector exists in areas that were never completed according to plan.4 Its predominant monumentality provides a useful contrast to the intimate spaces of the Rock Garden.In the 1950s, two men, Le Corbusier and Nek Chand Saini, began two very different projects within a kilometer of each other in Chandigarh. Le Corbusier's Capitol Complex started in the very highest government circles with Prime Minister Jawaharwal Nehru: the plan was to build a new state capital for a newly divided Punjab in a newly independent India. In architectural history, Chandigarh is well known and well studied due to its planning and design. Nek Chand's Rock Garden (under construction since 1958, and open to the public since 1976) began as an illegal private project by one man to give form to his imagination. This essay is my impressionistic response to these two projects.Monumental buildings often function powerfully as icons or as proud isolated structures. Visited on ceremonial occasions, they can provide visually compelling backdrops to large-scale... (shrink)

Abstract In his discourses on ‘the lily of the field and the bird of the air,’ Kierkegaard presents faith as the best possible response to our precarious and uncertain condition, and as the ideal way to cope with the insecurities and concerns that his readers will recognize as common features of human existence. Reading these discourses together, we are introduced to the portrait of a potential believer who, like the ‘divinely appointed teachers’—the lily and the bird—succeeds in leading a life (...) that is full of care, but free of worry. Such a portrait, we claim, echoes Kierkegaard’s portrait of the knight of faith in Fear and Trembling . In this essay we suggest that faith, as characterized in the ‘lily and bird’ discourses, is a kind of existential trust that would allow us to overcome worry, while remaining wholeheartedly engaged in the finite realm of our cares and concerns. We claim that Kierkegaard’s goal in these discourses is not to belittle our earthly cares, but to invite us to develop a modified attitude toward all that we are susceptible to worry about. Content Type Journal Article Category Article Pages 1-19 DOI 10.1007/s11153-011-9322-5 Authors Sharon Krishek, Department of Philosophy, The Hebrew University of Jerusalem, Jerusalem, Israel Rick Anthony Furtak, Department of Philosophy, Colorado College, Colorado Springs, CO, USA Journal International Journal for Philosophy of Religion Online ISSN 1572-8684 Print ISSN 0020-7047. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Literature 27.2 (2003) 428-435 [Access article in PDF] Agapic Friendship Sharon E. Sytsma ARISTOTLE CATEGORIZED FRIENDSHIP into three types: friendships of pleasure, friendships of utility, and complete (perfect or true) friendships (1156a5-10). 1 The thesis developed here is that Aristotle neglects an important kind of friendship. Various aspects of his theory of friendship have been challenged, but no one has charged that his categorization is incomplete. (...) 2 In what follows, an Aristotelian account of the friendship between James Steerforth and David Copperfield in Dickens' David Copperfield will be given, and then shown to be inadequate. Then a brief account of agapic love will be given and shown to be another basis of friendship—agapic friendship. Finally, the agapic nature of the two young men's friendship will be highlighted. I One might suppose that the friendship between David Copperfield and Steerforth is a mixed form of the three types of friendships identified by Aristotle. There can be no doubt that their friendship was pleasurable and useful to both. The two boys (and later young men) were appreciative of the other's pleasing appearance. David frequently comments on the pleasure attending any kind remark issuing from Steerforth on his own behalf. He admits his pleasure in being "cherished as a kind of plaything in my room," indicating his awareness of Steerforth's pleasure in being with him. Steerforth took great pleasure in David's imaginative and talented storytelling, which David eagerly [End Page 428] used as a "cementing" force in their relationship. Surely, Steerforth also took pleasure in the respect and admiration of his doting schoolmate.Also undeniable is that both friends found each other to be useful. David treasured the gift of Steerforth's protection. Being favored by Steerforth automatically elicited the admiration and envy of the other schoolboys. "No one dared to annoy one whom [Steerforth] honored with his countenance." Steerforth, on his part, found David's storytelling to be a useful antidote to his insomnia.However, David's love for Steerforth went beyond any self-interested concern. David loved Steerforth for his friend's own sake. He stayed up late and rose early to recount and embellish tales, not because he was motivated by self-interest or fear, but only because he "admired and loved him." David perceived Steerforth to be considerate and generous, and he mistook his friend's self-confidence as evidence of nobility of character.These perceptions were hardly objective. David's good nature, generous-mindedness, and youthful naiveté kept him from recognizing the faults in his friend's character, even in the face of ample evidence. Steerforth's cruel streak should have been obvious to David since he witnessed Steerforth allowing another student, the hapless Traddles, to take the blame when Steerforth laughed in church, and his ruthless exposure of Mr. Mell's secret shame of having a mother living on charity in an almshouse. He heard Steerforth's story about how he had "accidentally" thrown a hammer into Rosa Dartle's face. David's uneasiness on these occasions was overcome by his natural generosity of spirit and sense of gratitude. When shocked by a cold and arrogant insult against Little Em'ly's fiancé, Ham, David responds with full confidence: [You may] try to hide your sympathies in jest from me, but I know better. When I see how perfectly you understand them and how exquisitely you can enter into happiness like this plain fisherman's, or humour a love like my old nurse's, I know that there is not a joy or sorrow, not an emotion, of such people, that can be indifferent to you. And I admire and love you for it, Steerforth, twenty times the more! So even though David has an inflated sense of Steerforth's virtue, his thinking of Steerforth as virtuous was integral to their relationship, and that in itself would support thinking of the friendship as based on the good.Given Steerforth's defects of character, one might easily be led to the conclusion that Steerforth loved David only for the pleasure and [End Page 429] benefits of his... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Remembering Lewis E. HahnGeorge C. H. Sun, President, John Howie, Professor Emeritus, Thomas Alexander, Professor and Director of Graduate Studies, Kenneth W. Stikkers, Professor and Chair, Randall Auxier, Professor, Robert Hahn, Professor, Joseph Wu, Professor Emeritus, Elizabeth R. Eames, Professor Emeritus, Martin Lu, Professor of Philosophy, George Kimball Plochmann, Professor Emeritus, Matt Sronkoski, Philosophy Graduate and Academic Adviser, Dave Clarke, Professor Emeritus, Eugenie Gatens-Robinson, Professor Emerita, Hans H. Rudnick, (...) Professor Emeritus, Stephen Bickham, Professor EmeritusPresident, and Don Mikula (bio)The following testimonials were offered on the occasion of a memorial gathering for Dr. Lewis E. Hahn held on February 19, 2005, and were compiled for presentation here by Sharon (Hahn) Crowell.A Tribute to Dr. Lewis E. Hahn (1908-2004) from a Global PerspectiveGeorge C. H. Sun President, Thomé H. Fang Institute, Inc., Mobile, AlabamaAmong the philosophical community in both the East and the West, no word of introduction is needed for our beloved Master, who was the recipient of numerous distinctions and honors, with titles that included "Man of the Year in Philosophy" and "Award of Lifetime Achievement." The very name "Lewis E. Hahn" itself already stands now for genuineness, dedication, and fulfillment.A great work is a dialogue with eternity; a great person is such a work. In less than thirty years he succeeded in developing Carbondale from what had been a small college town in the Midwest into the Mecca of American philosophy. His most important achievements were the Dewey Center and the Pepper Archives that he helped install at SIUC These, among other such institutions, will remain a unique contribution, a glory of American philosophy, and a monument in the history of human thought.For posterity Lewis E. Hahn will remain an object of wonder and amazement. How is it possible for one human being to have accomplished so much, so well, and in so short a span of time—less than one century—in breadth, depth, and diversity? Some one hundred years ago, by bridging the gap between the New World and the Old, William James was hailed as the great genius of international friendship among philosophical thinkers, but we now find a greater genius in Lewis E. Hahn, who succeeded in bringing together the peoples of East and West from at least four continents: Europe, Australia, America (both North and Latin America), and Asia. To my knowledge, few of his predecessors and contemporaries have been half so widely read and liberal-minded as he was, in view of the range and scope of the Library of Living Philosophers that he helped continue after the passing of its founder, Dr. Paul A. Schilpp.What type of man was Hahn, our younger generation will wonder? Only a pluralist approach can help us understand the true character of such a legendary pluralist-contextualist. In short, he was "a full personality." As I recall, while working on my dissertation with him in the 1970s, we had a brief discussion on Confucius, the sage of ancient China. "A full personality!" was his laconic assessment. Suddenly I realized, to quote the Analects: "The Master is talking about himself!" For, as the Buddhists put it, only a Buddha can understand a Buddha. Or, as William James put it, only one who has philosophy can appreciate philosophy. Many friends [End Page 1] of my generation admire him so much; Te Chen of Hong Kong calls him "a great Confucian in America." Those who regret the loss of many precious Confucian virtues in China today have now rediscovered them in the person of Lewis E. Hahn! If Nietzsche called Kant "a great Chinese in Königsberg," it is simply because he had not encountered our own Master.A paradigm of academic leadership, Dr. Hahn is simply irreplaceable—this is a tribute I personally heard in Carbondale in the late 1960s. It is not an exaggeration to say that he was a superb administrator, and he could have been the best Secretary of the State we ever had, for he possessed more in the way of philosophical wisdom than all his predecessors put together! As a great teacher, he was no less "serene, good, learned, wise, and ardent" than... (shrink)

European Journal of Political Theory, Volume 21, Issue 2, Page 230-252, April 2022. The apparent inconsistency between Locke’s commitment to legalism and his explicit endorsement of the extra-legal power of prerogative has confounded many readers. Among those who don’t ignore or dismiss it, the common approach is to qualify the role or scope of prerogative. The article advocates the opposite approach. It argues that Locke’s legalism should be understood within the context of his oft neglected conception of political liberty (...) in terms of self-government. This not only allows for the reconciliation of Locke’s legalism with his endorsement of extra-legal powers, but also provides a fuller, more accurate account of the role of law and of political liberty in Locke’s theory. (shrink)

El relato de los viajes y la compilación de mirabilia de d'Abū Ḥāmid al- Ġarnāṭī —al-Mucrib can bacḍ cağā'ib al-Maġrib— se conocen hasta ahora por la edición, en dos partes , del manuscrito de Madrid. Sin embargo, el texto editado contiene blancos y rupturas en la narración, lo que demuestra que el manuscrito de base era defectuoso. Hemos encontrado cuatro manuscritos que permiten llenar estos blancos. Este artículo presenta la edición de estos pasajes, que hablan principalmente de los peces del (...) Mediterráneo y del viaje del autor entre Egipto y Azerbaiyan. (shrink)

How do young children learn how to talk about ethical concepts, such as fairness and equity? The current research assesses the effects of philosophy-based anti-bias lessons aimed at three to five-year-olds in a laboratory preschool and explores the relationship between socioemotional skills, language development, and understanding of ethical concepts. The constructivist curriculum was grounded in storybook lessons with corresponding activities. In a pre-posttest design, we interviewed children before and after lessons in fairness education that included book reading, related games, and (...) philosophical discussions. We found that children showed a significant increase in comprehension of equity-related terms and skin color awareness, and we found a positive relationship between children’s observed levels of community membership skills and their receptive vocabulary. In addition, receptive vocabulary skills predicted participant’s skin color awareness and their ability to tell a fairness narrative involving skin color following the lessons. The current study provides a framework for teachers to integrate ethical reasoning into a preschool curriculum and identifies some abilities occurring earlier than predicted by Jean Piaget. Given the divisive political climate surrounding anti-bias education, we hope that the present study encourages educators to put social emotional learning at the forefront of preschool pedagogy. (shrink)

Il y a naturellement un point de vue sociologique sur l'oecuménisme chrétien, point de vue d'autant plus légitime que l'oecuménisme se décline au pluriel. Mais ce même point de vue renvoie inévitablement aux divers conflits qui sont à l'origine des différenciations confessionnelles; ainsi se trouve pour une large part fondée et révélée l'importance anthropologique de la différence catholico-protestante. L'auteur cite au passage les chiffres d'enquêtes révélatrices de consciences d'appartenance et donc d'identité, avec pour effet des différences dans l'oecuménicité du vécu (...) religieux entre acteurs et organisations ecclésiastiques, ceci en raison d'un certain brouillage contemporain des différenciations confessionnelles. Par-delà les logiques de reconfessionalisations et de souci identitaire, l'auteur se demande si cette ultramodernité ne signe pas la fin de l'oecuménisme.Naturally, there is a sociological point of view about Christian ecumenism, a point of view all the more legitimate as ecumenism has many varieties. But this same point of view inevitably points to diverse conflicts that are at the origin of confessional differences. Thus, the anthropological importance of Catholic-Protestant differences are, for the most part, founded and revealed. Along the way the author cites the numbers in surveys that reveal the awareness of belonging, and therefore identity. The consequence is the difference between how ecclesiastical actors and organizations live religion ecumenically. This is due to a certain contemporary blurring of confessional differences. Beyond the logic of returning to one's confession and concern about identity, the author asks himself if this ultra modernity is not a sign of the end of ecumenism. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Leviathan after 350 YearsSharon VaughanTom Sorell and Luc Foisneau, editors. Leviathan after 350 Years. Oxford: Clarendon Press, 2004. Pp. x + 308. Cloth, $74.00The editors introduce this collection as a testament to the continuing importance of Leviathan in political thought. Divided into three parts, these twelve essays are some of the papers presented at a May 2001 conference to mark the 350th anniversary of Leviathan's publication. Readers might (...) expect a discussion about Leviathan's endurance and relevance as a fundamental text of political philosophy, but this is not the book's main thrust. Instead, the authors engage in a discussion concerning some of the most provocative and controversial questions about Leviathan. Much of the debate centers on how one should interpret it, forcing readers not only to reconsider crucial parts of Hobbes's philosophy, but also the act of interpretation.Part one examines the place that Leviathan holds among Hobbes's political writings. Karl Schumann argues that one should not think of Leviathan as a radical departure from De Cive and that it did not mark the culmination of Hobbes's development as a political philosopher (14). Schumann's essay is not convincing because he effectively points out the consequential ways that Leviathan is distinct. Ted H. Miller suggests, "Leviathan's uniqueness is rooted in its poetic-philosophical innovations"(103). He points out that David Johnston, Quentin Skinner, and others have stressed the significance of its rhetorical style. Miller, however, proposes that it was the context and the company that Hobbes kept during this time that influenced his writing style. Kinch Hoekstra suggests that Hobbes is an unusual de facto theorist and Luc Foisneau believes that Leviathan is unique because of its theory of justice.Part two is devoted to investigating passions and politics in Leviathan. Richard Tuck believes that Hobbes's political philosophy is utopian because it demands a radical transformation of humans as passionate beings. Tuck says that while the Leviathan provides citizens with security, "they are also going to live a life without pride, their sense of their own individual importance reduced to nothing in the face of their commonwealth" (138). Tuck's essay stands in contrast to Tom Sorrell's analysis of the burdens on the sovereign. He concludes that he must be an individual with little, if any, regard for his own ambitions and passions (196). What one is left with is a Hobbesian version of a philosopher king who has his personal appetites in check always looking out for what benefits his subjects. Is [End Page 210] there any guarantee that the sovereign will be non-egotistical and public-spirited? No, because the sovereign has absolute freedom. Sorrell believes, however, that it is in the sovereign's best interest to be unselfish if she is to maintain her sovereignty (193).Quentin Skinner analyzes the classical theory of laughter, relating it to Hobbes's complicated views about it. Political agency in Leviathan is Yves Zarka's topic. It seems that the citizen is merely a subject, but Zarka cautions that one must carefully read the text and remember that certain rights are inalienable. How far one may take what Zarka interprets as the "the right of resistance" remains a debatable question (182). He believes that one might rethink Leviathan as a more complex piece of political philosophy by practicing "back-to front reading" as opposed to a direct-method reading of the text (182). Zarka thinks that citizens may have a more complex and passionate role than commonly thought (182). This is an alluring suggestion, but it is difficult to accept in light of Hobbes's preoccupation with security and obedience.The role of biblical and political authority is the theme for part three. Edwin Curley argues that Hobbes's treatment of covenants with God was possibly a vehicle for him to arouse skepticism about Christianity among his readers. A. P. Martinich rejects Curley's claim and concludes that not only does his argument fail on grounds of logic, but also it requires far too much "reading between the lines" (223). Martinich's analytic rigor and his attention to the process of interpretation raise serious doubts about Curley... (shrink)

Volume 25, Issue 1, February 2020, Page 107-108.